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And finally, DIO does not actually tell you how much inventory cover you have. In our example, Company A had 100 days inventory outstanding. In a simplistic sense, this implies that they have enough inventory on hand to cover 100 days’ worth of sales. But, of course, they don’t, since DIO is just an average based on value. They actually have more or less than 100 days item by item – in a lot of cases much more or less. Alicic, R.Z.; Rooney, M.T.; Tuttle, K.R. Diabetic kidney disease: Challenges, progress, and possibilities. Clin. J. Am. Soc. Nephrol. 2017, 12, 2032–2045. [ Google Scholar] [ CrossRef] The second alternative, using a modification of cost of sales, may be done for a variety of reasons that no doubt make sense to the organisations employing it. In any case, it is fair to say that cost of sales calculations leave a fair amount to any organisation’s discretion. Generally Accepted Accounting Principles (GAAP) have relatively little to say about cost of sales. The accounting methods used (FIFO, LIFO, average cost method) will often have a material impact on the cost of sales recorded. Plus, inventory valuation and the speed of writing off obsolete inventory can be managed to influence short term figures. Controlling for all such variables is not possible. We think it is best to accept that DIO is an approximate metric and work with the simplest metrics, requiring a minimum of analysis of financial statements. Release Date Delay Notice and Apology for MEDICOS ENTERTAINMENT's Nendoroid DIO (Rerelease) (2022/09/09) A high DIO figure simply means a company is taking longer to convert its inventory into cash. The longer the period the higher the DIO ratio.

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Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495–516. [ Google Scholar] [ CrossRef] Fernyhough, P.; Huang, T.J.; Verkhratsky, A. Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy. J. Peripher. Nerv. Syst. 2003, 8, 227–235. [ Google Scholar] [ CrossRef] [ PubMed] Also, a company must consider the factors affecting the days inventory outstanding. For instance, does the external economic conditions slow down the sales of a company that compels a company to keep inventory for long?

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Yang, K.; Bai, Y.; Yu, N.; Lu, B.; Han, G.; Yin, C.; Pang, Z. Huidouba improved podocyte injury by down-regulating Nox4 expression in rats with diabetic nephropathy. Front. Pharmacol. 2020, 11, 587995. [ Google Scholar] [ CrossRef] [ PubMed] Zhong, Y.J.; Liu, J.Y.; Sun, D.J.; Guo, T.M.; Yao, Y.P.; Xia, X.D.; Shi, C.; Peng, X.L. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control. Food Funct. 2022, 13, 3660–3673. [ Google Scholar] [ CrossRef] Days inventory outstanding (DIO) is an important working capital ratio. It also shows the operating efficiency and short-term liquidity positions of a company.

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Mohamadi-Zarch, S.M.; Baluchnejadmojarad, T.; Nourabadi, D.; Khanizadeh, A.M.; Roghani, M. Protective effect of diosgenin on LPS/D-Gal-induced acute liver failure in C57BL/6 mice. Microb. Pathog. 2020, 146, 104243. [ Google Scholar] [ CrossRef] Balaban, R.S.; Nemoto, S.; Finkel, T. Mitochondria, oxidants, and aging. Cell 2005, 120, 483–495. [ Google Scholar] [ CrossRef] Zhong, Y.J.; Jin, C.N.; Han, J.H.; Zhu, J.C.; Liu, Q.; Sun, D.J.; Xia, X.D.; Peng, X.L. Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca 2+ homeostasis. Cell Biol. Toxicol. 2021, 37, 795–809. [ Google Scholar] [ CrossRef] [ PubMed] From the anime series "JoJo's Bizarre Adventure: Stardust Crusaders" comes a rerelease of the Nendoroid of the longtime enemy of the Joestar family, DIO! The figure is fully articulated so you can display him in a wide variety of poses. He comes with three face plates including his standard expression, his sneering expression and his crazed expression. Days in Period means the number of days in the period, such as an accounting period, that is being examined – the period may be any time frame – a week, a quarter, or annuallyEftekharpour, E.; Fernyhough, P. Oxidative stress and mitochondrial dysfunction associated with peripheral neuropathy in type I diabetes. Antioxid. Redox Signal. 2021, 37, 578–596. [ Google Scholar] [ CrossRef] Qi, W.; Mu, J.; Luo, Z.F.; Zeng, W.; Guo, Y.H.; Pang, Q.; Ye, Z.L.; Liu, L.; Yuan, F.H.; Feng, B. Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response. Metab.-Clin. Exp. 2011, 60, 594–603. [ Google Scholar] [ CrossRef] [ PubMed] Geiszt, M.; Kopp, J.B.; Varnai, P.; Leto, T.L. Identification of Renox, an NAD(P)H oxidase in kidney. Proc. Natl. Acad. Sci. USA 2000, 97, 8010–8014. [ Google Scholar] [ CrossRef] [ PubMed] He, T.; Xiong, J.; Nie, L.; Yu, Y.; Guan, X.; Xu, X.; Xiao, T.; Yang, K.; Liu, L.; Zhang, D.; et al. Resveratrol inhibits renal interstitial fibrosis in diabetic nephropathy by regulating AMPK/NOX4/ROS pathway. J. Mol. Med. 2016, 94, 1359–1371. [ Google Scholar] [ CrossRef] [ PubMed]

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Roghani-Dehkordi, F.; Roghani, M.; Baluchnejadmojarad, T. Diosgenin mitigates streptozotocin diabetes-induced vascular dysfunction of the rat aorta: The involved mechanisms. J. Cardiovasc. Pharmacol. 2015, 66, 584–592. [ Google Scholar] [ CrossRef] [ PubMed] Kowaltowski, A.J.; de Souza-Pinto, N.C.; Castilho, R.F.; Vercesi, A.E. Mitochondria and reactive oxygen species. Free Radic. Biol. Med. 2009, 47, 333–343. [ Google Scholar] [ CrossRef] Days Inventory Outstanding is the value of inventory held divided by an average day’s cost of sales.

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Prasad, M.K.; Mohandas, S.; Ramkumar, K.M. Role of ER stress inhibitors in the management of diabetes. Eur. J. Pharmacol. 2022, 922, 174893. [ Google Scholar] [ CrossRef] Vasavada, N.; Agarwal, R. Role of oxidative stress in diabetic nephropathy. Chronic Kidney Dis. 2005, 12, 146–154. [ Google Scholar] [ CrossRef] [ PubMed]