Aduna Super-Cacao Powder | Natural Raw African Cacao Powder for Cardiovascular Health | Ghanaian Low Cadmium Cacao | 275g Resealable and Recyclable Pack

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Given the above, it has been proposed that flavanols may protect the integrity and function of the cell membrane by modulating changes in its fluidity and permeability produced by molecules with oxidation potential [ 37, 38]. NUTRITIOUS Organic Alkalised Cocoa Powder: Alkaline cocoa, often known as "Dutch" cocoa or "European style," is cocoa that has been processed to neutralize the cocoa's naturally strong acidity. Alkaline cocoa is darker and has a smooth taste that is commonly seen in earthy woody flavors. Wagner, J.A.; Tennen, H.; Finan, P.H.; White, W.B.; Burg, M.M.; Ghuman, N. Lifetime History of Depression, Type 2 Diabetes, and Endothelial Reactivity to Acute Stress in Postmenopausal Women. Int. J. Behav. Med. 2012, 19, 503–511. [ Google Scholar] [ CrossRef] [ PubMed]

Corretti, M.C.; Anderson, T.J.; Benjamin, E.J.; Celermajer, D.; Charbonneau, F.; Creager, M.A.; Deanfield, J.; Drexler, H.; Gerhard-Herman, M.; Herrington, D.; et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force. J. Am. Coll. Cardiol. 2002, 39, 257–265. [ Google Scholar] [ CrossRef][ Green Version] When considering the health benefits of cocoa powder, several factors contribute to what makes it the best for health. Here are the scientific factors to consider: As for the nutritional content, this cacao powder is a powerhouse. Just one ounce provides a good source of essential minerals and vitamins. It’s also free from any additives or sugar, making it a healthy choice for those seeking a nutrient-dense food supplement.

100% Natural High-Flavanol Cacao Powder 

Heart Health: The antioxidants in cocoa powder, called flavonoids, have been associated with potential cardiovascular benefits, including reducing the risk of heart disease. This was confirmed when the interaction of flavanols and procyanidins (dimers to hexamers) with liposomes (composed of phosphatidylcholine and phosphatidylserin) did not influence its membrane fluidity or lipid lateral phase separation [ 39]. AL-Ishaq RK, Abotaleb M, Kubatka P, Kajo K, Büsselberg D. Flavonoids and their anti-diabetic effects: cellular mechanisms and effects to improve blood sugar levels. Biomolecules. 2019;9(9):430. doi:10.3390/biom9090430 Cassidy, A.; Bertoia, M.; Chiuve, S.; Flint, A.; Forman, J.; Rimm, E.B. Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men. Am. J. Clin. Nutr. 2016, 104, 587–594. [ Google Scholar] [ CrossRef][ Green Version]

Hugo Van Der Goes, Vice President Cocoa North America, Barry Callebaut, said for its customers, it presents an opportunity to develop and enhance better-for-you products leveraging high-flavanol cocoa powder, especially in the sports beverage and protein mix categories, to meet consumer demand

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Both DOCA-salt–EPI2 and EPI10 restored impaired endothelial function due to an ↑ in eNOS phosphorylation and a ↓ in O 2 − vascular content

When the pods are ripe, they are cut from the trees by hand using a large knife, taking care not to damage any buds or flowers near the fruit. The Food and Drug Administration (FDA) stipulates that cocoa powder must contain at least 10% cocoa butter. However, many brands do the bare minimum to meet this requirement, primarily to keep production costs low. Although cocoa butter is costly, it brings a unique richness to cocoa powder that can’t be replicated.Leor, J.; Kloner, R.A. The Northridge earthquake as a trigger for acute myocardial infarction. Am. J. Cardiol. 1996, 77, 1230–1232. [ Google Scholar] [ CrossRef] Pretreatment of bovine aortic endothelial cells (BAEC) with (-)-epicatechin prevented oxLDL-elicited down-regulation of eNOS protein and partially the up-regulation of iNOS protein, thus shifting the eNOS/iNOS ratio toward preferencial expression of eNOS protein [ 67]. Usage is simple and versatile. It can be easily mixed into hot beverages, smoothies, or dairy-based products. The recommended procedure is to add the powder to a hot beverage without boiling it first, preserving all its beneficial nutrients.

Epicatechin (1 μM/L) induced eNOS activation via Ser1177 and Ser633 phosphorylation and Thr495 de-phosphorylation At 100 nM, B1 and B2 caused a 29–38% and 38–47% inhibition of either p50 or RelA binding to its DNA consensus sequence Alsolmei, F.A.; Li, H.; Pereira, S.L.; Krishnan, P.; Johns, P.W.; Siddiqui, R.A. Polyphenol-Enriched Plum Extract Enhances Myotubule Formation and Anabolism while Attenuating Colon Cancer-induced Cellular Damage in C2C12 Cells. Nutrients 2019, 11, 1077. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] Toda, N.; Nakanishi-Toda, M. How mental stress affects endothelial function. Pflugers Arch. 2011, 462, 779–794. [ Google Scholar] [ CrossRef]

It has been determined that the presence of a mono methylated catechol ring is essential for the inhibitory effect of apocynin, 3′-O-methyl (-)-epicatechin and 4′-O-methyl (-)-epicatechin on Nox activity [ 54, 55]. The latter was corroborated when incubation of 3′-O-methyl (-)-epicatechin in the presence of 3,5-dinitrocatechol (DNC), an inhibitor of catechol-O-methyltransferase (COMT), showed an increase in the production of O 2 − and a decrease in the concentration of NO, due to its reaction with O 2 − to form peroxynitrite (ONOO −) [ 53]. Gottdiener, J.S.; Kop, W.J.; Hausner, E.; McCeney, M.K.; Herrington, D.; Krantz, D.S. Effects of mental stress on flow-mediated brachial arterial dilation and influence of behavioral factors and hypercholesterolemia in subjects without cardiovascular disease. Am. J. Cardiol. 2003, 92, 687–691. [ Google Scholar] [ CrossRef] Additionally, there has been a growing interest in the ability of flavanols to chelate redox-active metals (iron and copper). In biological systems, oxidative stress breaks iron homeostasis and increases its intracellular concentration, promoting free radical-producing reactions and increasing DNA oxidative damage [ 41, 42]. Wholefood Earth’s Organic Alkalised Cocoa Powder is a standout product that offers many nutritional benefits while maintaining a high quality and taste.