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Unlike oral carbonic anhydrase inhibitors, topical administration of dorzolamide hydrochloride allows for the active substance to exert its effects directly in the eye at substantially lower doses and therefore with less systemic exposure. In clinical trials with dorzolamide, this resulted in a reduction in IOP without the acid-base disturbances or alterations in electrolytes characteristic of oral carbonic anhydrase inhibitors. If you develop allergic reactions including hives, swelling of the face, lips, tongue, and/or throat which may cause difficulty in breathing or swallowing, you should stop using this medicine and seek immediate medical advice.
Choroidal detachment concomitant with ocular hypotony have been reported after filtration procedures with administration of aqueous suppressant therapies. Repeat the instructions 2. – 5. to deliver a drop into the other eye also, if your doctor has instructed you to do this. Sometimes only one eye needs to be treated and your doctor will advise if this applies to you and which eye needs treatment. Composition: Sodium hyaluronate cross polymer aqueous solution (of which sodium hyaluronate cross polymer 0,4%), Trometamol, Hydrochloric acid 2N, Sodium chloride, water for injection. Instructions 2. – 4. should be repeated for delivery into the other eye, if required. The patient should be clearly instructed if one eye only requires treatment, and if so, which eye is affected. Prescribing VIZcellose (carmellose) eye drops by brand could cut over 60% from CCG prescribing costs without compromising patient care. Presentation
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For patients who are allergic to lanolin, alternative lanolin-free eye ointment can be obtained from specialist. Systane Balance (propylene glycol 0.6%) or Optive Plus (carboxymethylcellulose 0.5%, glycerine 1%, castor oil). 10ml, 6m expiry, contains preservative. If blepharitis or evaporative dry eye: use Systane Balance (propylene glycol 0.6%) or Optive Plus (carboxymethylcellulose 0.5%, glycerine 1%, castor oil), 10ml, 6m expiry. Vizidor eye drops solution is a sterile solution that does not contain a preservative. The solution from the multi-dose container can be used for up to 28 days after first opening for administration to the affected eye(s). Hylo-Tear*** 0.1% or Hylo-Forte*** 0.2%. 300 drops metered dose bottle, 6m expiry. Can prescribe ComplEYE aid.
Close your eye and press the inner corner of the eye with your finger for about two minutes. This helps to stop the medicine from getting into the rest of the body. Hydroxypropyl guar or combination product containing trehalose can be used for more severe symptoms as they can reduce inflammation and protect ocular surface. Therapy with oral carbonic anhydrase inhibitors has been associated with urolithiasis as a result of acid-base disturbances, especially in patients with a prior history of renal calculi. Although no acid-base disturbances have been observed with dorzolamide, urolithiasis has been reported infrequently. Because dorzolamide is a topical carbonic anhydrase inhibitor that is absorbed systemically, patients with a prior history of renal calculi may be at increased risk of urolithiasis while using dorzolamide. VIZhyal 0.1% is a sterile, ophthalmic solution that soothes and moisturizes the ocular surface to alleviate symptoms associated with moderate dry eyes, such as burning, irritation and foreign body sensation. VIZhyal 0.1% acts as a humectant on the eye, providing relief of dry eye conditions, including those associated with the use of PC, infrequent blinking, medical treatments, atmospheric pollution, air conditioning, central heating, wind and sun.
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superficial punctate keratitis, tearing, conjunctivitis, eyelid inflammation, eye itching, eyelid irritation, blurred vision Recommend overnight treatment with a paraffin-based PF eye ointment: Xailin Night or Hylo-Night (formerly known as VitA-POS) or HydraMed Night Eye Ointments, 5g. Hypromellose 0.3% eye drop, use frequently prn. Consider switching to PF drops if using more than 8 times a day. Limited clinical data in pediatric patients with administration of dorzolamide (preserved formulation) three times a day are available. (For information regarding pediatric dosing see section 5.1). The patient should close the eye and press the inner corner of the eye with a finger for about two minutes. This helps to stop the medicine from getting into the rest of the body.
When used as monotherapy, the dose is one drop of dorzolamide in the conjunctival sac of the affected eye(s), three times daily. Pharmacotherapeutic group: Antiglaucoma preparations and miotics, Carbonic Anhydrase Inhibitors, dorzolamide, ATC code: S01EC03 Buffered solution with Calendula extract, Hamamelis extract, EDTA 0.12%, PHMB 0.0001%. Storage instructions
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The following side effects have been reported with dorzolamide preservative free either during clinical trials or during post-marketing experience:
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