Lattoferrina 200 Immuno 30 Stick Pack PromoPharma

Product Information

Come anticipato, il primo latte che la donna produce dopo il parto, il colostro, è particolarmente ricco di lattoferrina, che favorisce lo sviluppo di batteri intestinalibenefici, aiutando il piccolo a debellare i patogeni responsabili delle gastroenteriti( coliche del neonato). Troost FJ, Saris WH, Brummer RJ. Orally ingested human lactoferrin is digested and secreted in the upper gastrointestinal tract in vivo in women with ileostomies. J Nutr 2002;132:2597-600. View abstract. Levay PF, Viljoen M (1995). "Lactoferrin: a general review". Haematologica. 80 (3): 252–67. PMID 7672721.

Azzam HS, Goertz C, Fritts M, Jonas WB (February 2007). "Natural products and chronic hepatitis C virus". Liver International. 27 (1): 17–25. doi: 10.1111/j.1478-3231.2006.01408.x. PMID 17241377. S2CID 7732075.Rogan MP, Taggart CC, Greene CM, Murphy PG, O'Neill SJ, McElvaney NG (October 2004). "Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis". The Journal of Infectious Diseases. 190 (7): 1245–53. doi: 10.1086/423821. PMID 15346334. a b van der Strate BW, Beljaars L, Molema G, Harmsen MC, Meijer DK (December 2001). "Antiviral activities of lactoferrin". Antiviral Research. 52 (3): 225–239. CiteSeerX 10.1.1.104.745. doi: 10.1016/S0166-3542(01)00195-4. PMID 11675140. Shortly after the emergence of COVID-19 in China, causing a global health crisis on a scale that has not been evidence in the last century ( 8). In the first days of January 2020, the reported number of patients that were diagnosed with COVID-19 infection was reported to be only 41 ( 9). Just within a few weeks, on January 30th, 2020, WHO declared the outbreak of COVID-19 as a Public Health Emergency of International Concern (PHEIC) ( 10). On July 8th, 2020, the coronavirus spread across 216 cities worldwide. Globally, as of 28th June 2022, there have been 542,188,789 confirmed cases of COVID-19 including 6,239,275 deaths, reported to WHO. Harmsen MC, Swart PJ, de Béthune MP, Pauwels R, De Clercq E, The TH, Meijer DK (August 1995). "Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro". The Journal of Infectious Diseases. 172 (2): 380–388. doi: 10.1093/infdis/172.2.380. PMID 7622881.

Tong PL, West NP, Cox AJ, et al. Oral supplementation with bovine whey-derived Ig-rich fraction and lactoferrin improves SCORAD and DLQI in atopic dermatitis. J Dermatol Sci. 2017;85(2):143-146. View abstract. a b Puddu P, Borghi P, Gessani S, Valenti P, Belardelli F, Seganti L (September 1998). "Antiviral effect of bovine lactoferrin saturated with metal ions on early steps of human immunodeficiency virus type 1 infection". The International Journal of Biochemistry & Cell Biology. 30 (9): 1055–1062. doi: 10.1016/S1357-2725(98)00066-1. hdl: 11573/83805. PMID 9785469. Negli integratori la lattoferrina è generalmente presente insieme a sostanze dotate di azione sinergica, come ceppi probioticie FOS. Per approfondire: Regarding Lf's antiviral effect against SARS-CoV-2, some significant studies have been conducted based on the analysis of different parameters ( 73, 81, 101, 102). In one of these in-vivo studies, 75 patients with a positive result at IgM/IgG rapid test have participated. Each patient took liposomal bLf syrup (32 mg of Lf/10 ml) with four to six doses, each dose containing 10 mg/10 ml syrup, every day for 10 days. The patients who were given syrup were observed for 10 days at least twice a day then they were investigated again after 30 days. As a result of the investigation, Lf treatment had shown a positive effect and all patients had a faster recovery when compared with the control group ( 81). Rawat P, Kumar S, Sheokand N, Raje CI, Raje M (June 2012). "The multifunctional glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a novel macrophage lactoferrin receptor". Biochemistry and Cell Biology. 90 (3): 329–38. doi: 10.1139/o11-058. PMID 22292499.

Supplementary Material

It is suggested that the oligomer state of lactoferrin is determined by its concentration and that polymerization of lactoferrin is strongly affected by the presence of Ca 2+ ions. In particular, monomers were dominant at concentrations below 10 −10−10 −11 M in the presence of Ca 2+, but they converted into tetramers at lactoferrin concentrations above 10 −9−10 −10 M. [27] [30] Titer of lactoferrin in the blood corresponds to this particular "transition concentration" and thus lactoferrin in the blood should be presented both as a monomer and tetramer. Many functional properties of lactoferrin depend on its oligomeric state. In particular, monomeric, but not tetrameric lactoferrin can strongly bind to DNA. Dobryk D, Dobryk O, Dobryanskyy D. The effect of enteral lactoferrin supplementation in prevention of morbidity associated with immature digestive tract in premature infants: prospective cohort study. Georgian Med News 2022;(323):94-101. View abstract.